: 연세대학교 생활과학대학 식품영양학과 부교수
: 효소공학 및 식품가공
: 식품 탄수화물ㆍ효소공학, 당질학, 기능성 탄수화물,
  효소적 생물전환, 식품생물공학, 극한환경효소, 단백질 공학
: 연세대학교 생활과학대학(삼성관) 526호
: 02-2123-3124
: soobok@yonsei.ac.kr
     
 
1993.04 - 1997.01 : 일본 Kyoto대학교 식품공학과 박사과정 수학 / 박사(Ph.D.)학위 취득
전공 : 효소공학 (Enzyme Chemistry and Engineering)
1990.03 - 1992.02 : 서울대학교 식품공학과 석사(M.S.)
1985.03 - 1990.02 : 서울대학교 식품공학과 학사(B.S.)
 
2008-2009 : 한국식품과학회 Food Science and Biotechnology (영문지, SCIE) 편집간사
2006-2007 : 한국식품과학회 식품과학회지(국문지) 편집자
2007.01-2007.02 : 일본 Hokkaido University, Molecular Enzymology Lab 방문연구
2006.10 : 서울시 산학연 신기술개발과제 평가위원
2006.08 - 2006.09 : 특허청 변리사시험 선정 및 채점위원
2006.03 : 2차 BK21 핵심 심사위원
2006.03 - 현재 : 한국식품과학회 학회지 편집자
2005.09 - 현재 : 연세대학교 생활과학대학 식품영양학과 부교수, 학과장
2002.03 - 2005.08 : 연세대학교 생활과학대학 식품영양학과 조교수
1999.09 - 2002.02 : 건국대학교 농축산생명과학대학 조교수
2001.12 - 2002.02 : 미국 Iowa State Univ. Dept of Animal Science 방문연구
1997.02 - 1999.10 : 미국 Iowa State Univ. 생화학분자생물학과 박사후연구원
1992.08 - 1992.12 : 한국식품개발연구원 생물공학실 연구원
 
Soo-Bok Lee, Soo-In Ryu, Hye-Min Kim, Bong-Gwan Kim ( 2008. 9)
Enzymatic synthesis and properties of trehalose analogues as disaccharide and trisaccharide. pp 258-265. In: Carbohydrate-active enzymes. Structure, function, and applications. K-H Park (Ed). Woodhead Publishing Limited and CRC Press LLC, Cambridge, England.
 
연세대학교 산학협력단 (발명자:이수복,류수인,김은주,장혜영,김혜민)
신규한 뉴클레오시드 디포스페이트-글루코오스 합성효소 및 이를 이용한 뉴클레오시드 디포스페이트-글루코오스의 생산방법{Novel nucleoside diphosphate-glucose synthetase and production method of nucleoside diphosphate-glucose using the same}
대한민국, 특허등록번호 : 제10-0984567, 등록일: 2010년 9월24일
 

Seung-Kyung Chung, Soo-In Ryu, Soo-Bok Lee* Characterization of UDP-glucose 4-epimerase from Pyrococcus horikoshii : Regeneration of UDP to produce UDP-galactose using two-enzyme system with trehalose. Bioresource Technology 110 : 423–429, 2012

Young-Su Lee, Ji-Young Huh, So-Hyun Nam, Sung-Kwon Moon, Soo-Bok Lee* Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori. Food Chem. 135 (4) : 2253–2259, 2012

Hye-Young Chang, Yoon-Bok Lee, Hyun-Ah Bae, Ji-Young Huh, So-Hyun Nam, Heon-Soo Sohn, Hyong Joo Lee, and Soo-Bok Lee.* Purification and characterisation of Aspergillus sojae naringinase: The production of prunin exhibiting markedly enhanced solubility with in vitro inhibition of HMG-CoA reductase. 2011 ;124-1(1):234-241.

Soo-In Ryu, Jeong-Eun Kim, Eun-Joo Kim, Seung-Kyung Chung, and Soo-BokLee.
Catalytic reversibility of Pyrococcus horikoshii trehalose synthase: Efficientsynthesis of
several nucleoside diphosphate glucoses with enzyme recycling. 2011;46-1:128-134.

Soo-In Ryua,1, Jeong-Eun Kima,1, Nguyen Thi Huonga, Eui-Jeon Woob,
Sung-Kwon Moonc, Soo-Bok Leea,? Molecular cloning and characterization of trehalose synthase from Thermotoga maritima DSM3109: Syntheses of trehalose disaccharide analogues and NDP-glucoses. 2010 ;47-6(8):249-256.

Woo EJ, Ryu SI, Song HN, Jung TY, Yeon SM, Lee HA, Park BC, Park KH,
Lee SB.* Structural insights on the new mechanism of trehalose synthesis by trehalose synthase TreT from Pyrococcus horikoshii. 2010 ;26-404(2):247-259.

Purification and Characterization of Branching Specificity of a Novel Extracellular Amylolytic Enzyme from Marine Hyperthermophilic Rhodothermusmarinus.Journal of Microbiology and Biotechnology 18(3):457-464, 2008 (SCIE)

Biochemical characterisation of a glycogen branching enzyme from Streptococcus mutans: Enzymatic modification of starch. FoodChemistry 110(4):979-984, 2008

Enzymatic synthesis and characterization of galactosyl trehalose trisaccharides. FoodSci. Biotechnol16(1), 2007 (SCIE)

Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis. 29(9):1701-1709, 2008

Enzymatic synthesis of a galactose-containing trehalose analogue disaccharide by Pyrococcus horikoshii trehalose-synthesizing glycosyltransferase: Inhibitory effects on several disaccharidase activities. Journal of Molecular Catalysis B: Enzymatic, Volume 49, Issues 1-4, 2007, Pages 98-103

Cloning and Characterization of Glycogen-Debranching Enzyme from Hyperthermophilic Archaeon Sulfolobus shibata J Microbiol Biotechnol. 2007;17(5):792-9

Inhibitory role of magnolol on proliferative capacity and matrix metalloproteinase-9 expression in TNF-alpha-induced vascular smooth muscle cells.Int Immunopharmacol. 2007;7(8):1083-91.

Evaluation of enhanced hygroscopicity, bifidogenicity, and anticariogenicity of enzymatically synthesized beta-galactosyl-trehalose oligosaccharides. 1: J Agric Food Chem. 2007;55(10):4184-8.

Properties of a Novel Glycogen Branching Enzyme from Streptococcus mutans to Synthesize Branched Glucans with Specified Short Chains from Amylose. Applied and Environmental Microbiology 2006

Evaluation of the Hygroscopic, Maillard Browning, Bifidogenic, and Anti-cariogenic Properties of Enzymatically Synthesized β-Galactosyl-trehalose Oligosaccharides. Journal of Agricultural and Food Chemistry 2006

Cryo- and Thermo-protective Effects of Enzymatically Synthesized β-Galactosyl-trehalose Trisaccharide. Food Sci. Biotechnol. 17(1):199-202, 2008

A novel trehalose-synthesizing glycosyltransferase from Pyrococcus horikoshii: Molecular cloning and characterization. Biochemical and Biophysical Research Communications 329:429-436, 2005

Enzyme chemistry of cyclodextrin hydrolase and its application to food science and technology. Bioindustry 23(10):66-73, 2006
Production of new sucrose derivative by transglycosylation of recombinant Sulfolobus shibatae β-glycosidase. Carbohydrate Research 340(6):1089-1096, 2005

The hypoglycemic effects of acarviosine-glucose modulate hepatic and intestinal glucose transporters in vivo. FoodSci. Biotechnol.15(6):851-855, 2006 (SCIE)

Enzyme chemistry of cyclodextrin hydrolase and its application to food science and technology. Bioindustry 23(10):66-73, 2006

Substrate specificity and transglycosylation catalyzed by a thermostable β-glucosidase from marine hyperthermophile Thermotoga neapolitana. Applied Microbiology and Biotechnology 69(4):411-422, 2005

Affinity immobilization of dextransucrase on dextran-based support and the production of leucrose. Food Sci Biotechnol 14(3):317-322, 2005

Soy isoflavones and soyasaponins: characteristics and physiological functions. Agric Chem Biotechnol 48(2): 49-57, 2005

Antioxidative effects of glycosyl-ascorbic acids synthesized by maltogenic amylase to reduce lipid oxidation and volatiles production in cooked chicken meat. Bioscience, Biotechnology, and Biochemistry 68:36-43, 2004

Enzymatic synthesis of acarbose oligosaccharide analogues as new enzyme inhibitors. ACS symposium series 849:168-181, 2003

Preparation and characterization of maltosyl-sucrose isomers produced by transglycosylation of maltogenic amylase from Bacillus stearothermophilus. Journal of Molecular Catalysis B: Enzymatic 26:293-305, 2003

Directed Evolution of Thermus Maltogenic Amylase toward Enhanced Thermal Resistance. Applied and Environmental Microbiology 69:4866-4874, 2003

Acarviosine-simmondsin, a novel compound obtained from acarviosine-glucose and simmondsin by Thermus maltogenic amylase and its in vivo effect on food intake and hyperglycemia. Bioscience, Biotechnology, and Biochemistry 67:532-539, 2003

Modification of ascorbic acid using transglycosylation activity of Bacillus stearothermophilus maltogenic amylase to enhance its oxidative stability. Journal of Agricultural and Food Chemistry 50:3309-3316, 2002

Modulation of the multisubstrate specificity of Thermus maltogenic amylase by truncation of the N-terminal domain and by a salt-induced shift of the monomer/dimer equilibrium. Biochemistry 40:14182-14190, 2001

Purification and characterization of a fibrinolytic enzyme from Bacillus sp. KDO-13 isolated from soybean paste . Journal of Microbiology and Biotechnology 11(5):845-852, 2001

Trapping of the covalent enzyme-substrate intermediate in the reaction of cyclodextrin glycosyltransferase with cyclomaltohexaose. Carbohydrate Research 336:47-53, 2001

Inhibition of β-glycosidases by acarbose analogues containing cellobiose and lactose structures. Carbohydrate Research 331:13-18, 2001

Synthesis of acarbose transfer products by Bacillus stearothermophilus maltogenic amylase with simmondsin. Industrial Crops and Products 12:173-182, 2000

The role of the glutamate 332 residue in the transglycosylation activity of Thermus maltogenic amylase. Biochemistry 39:6773-6780, 2000

Molecular characterization of a dimeric intracellular maltogenic amylase of Bacillus subtilis SUH4-2. Biochim. Biophys Acta 1478:333-340, 2000

Comparative study of the inhibition of α-glucosidase, α-amylase, and cyclomaltodextrin glucanosyltransferase by acarbose, isoacarbose, and acarviosine-glucose. Arch of Biochem Biophys 371:277-283, 1999

Analysis of the gene encoding cyclomaltodextrinase from alkalophilic Bacillus sp. I-5 and characterization of enzymatic properties. Arch. of Biochem Biophys 353:221-227, 1998

Effects of nitration and amination of tyrosyl residues in thermolysin on its hydrolytic activity and its remarkable activation by salts. J Biochem 124:72-78, 1998

Effects of pH, temperature, and alcohols on the remarkable activation of thermolysin by salts. J Biochem 122:358-364, 1997

The states of tyrosyl residues in thermolysin as examined by nitration and pH- dependent ionization. J Biochem 121:231-237, 1997

Effect of amino acid residues at the cleavable site of substrates on the remarkable activation of thermolysin by salts. Biochem J 315:133-138, 1996

 
Discrimination of geographical origin for herbal medicine by mineral content analysis with energy dispersive X-ray fluorescence spectrometer. Korean J. Food Sci. Technol. 40(2):135-140, 2008 (에너지분산형 X-선 형광분석기를 이용한 한약재의 무기질 분석 및 이에 의한 원산지 판별)